SCIENCE: RESEARCH ON CROHN’S DISEASE AND GLUTEN

Once viewed as an useless fad, new scientific studies and research is consistently finding that going gluten free can be incredibly beneficial for people suffering from Crohn’s disease.

Even in people without Crohn’s Disease, IBD,Celiac, or Gluten Intolerance, gluten has been shown to cause inflammation!

(http://jn.nutrition.org/content/145/6/1256.abstract)

The following are just a few of the many papers and studies that show the effectiveness and benefits of a gluten free diet:

“Prevalence of celiac disease seems to be high among patients affected by CD [Crohn’s Disease], and this finding should be kept in mind at the time of the first diagnosis of CD; a gluten-free diet should be promptly started.

(http://www.ncbi.nlm.nih.gov/pubmed/15973121)

“Prescription drugs and surgery are two common medical therapies for Crohn’s disease (CD), an inflammatory bowel disease that affects the GI tract. Unfortunately, certain drugs can cause serious side effects, and surgeries must often be repeated. No diet has been established to alleviate the pain and suffering of CD patients. This is curious given the fact that a higher prevalence of food sensitivities exist in this population of patients, and enteral nutrition is not only the first-line of therapy in Japan, but a known research method used to place the majority of CD [Crohn’s Disease] patients into remission. Although not all patients respond equally to diet, many simply remove symptom-provoking foods, such as dairy, wheat, corn and certain fruits and vegetables. We suggest assisting these patients in their self-assessment of irritating and symptom-provoking foods by educating them in the use of a food-symptom diary followed by a customized elimination diet trialed for 2-4 weeks to determine if there is any benefit to the individual patient.

(http://www.ncbi.nlm.nih.gov/pubmed/20350266)

In a cross-sectional study of 1647 patients with IBD [Inflammatory Bowel Disease], “65.6% of all patients, who attempted a GFD [gluten free diet] described an improvement of their GI-symptoms,” and , “excellent adherence [to a gluten free diet] was associated with significant improvement of fatigue… In this large group of patients with IBD, a substantial number had attempted a GFD, of whom the majority had some form of improvement in GI-symptoms. Testing a GFD in clinical practice in patients with significant intestinal symptoms, which are not solely explained by the degree of intestinal inflammation, has the potential to be a safe and highly efficient therapeutic approach.”

(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331053/)

Celiac disease (CD) and nonceliac gluten sensitivity (NCGS) are two distinct conditions triggered by the ingestion of gliadin. Although symptoms of nonceliac gluten sensitivity may resemble those of celiac disease, due to the lack of objective diagnostic tests, NCGS is associated with overlapping symptomatologies of autoimmunities and Crohn’s disease. Furthermore, a gluten-free diet is only recommended for those who meet the criteria for a diagnosis of CD. Unfortunately, that leaves many nonceliac gluten-sensitive people suffering unnecessarily from very serious symptoms that put them at risk for complications of autoimmune disorders that might be resolved with a gluten-free diet. 

(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207593/)

Celiac Disease and Inflammatory Bowel Disease-IBD (Crohn’s Disease and Ulcerative Colitis) are chronic inflammatory condition of the Gastro-Intestinal Tract. The prevalence of IBD in Celiac Patients has been reported as 5-10 times higher than that in the general population.

NCGS is characterized by intestinal and extra intestinal symptoms due to the ingestion of gluten-containing food in subject without Celiac Disease and/or Wheat Allergy.

(http://www.ncbi.nlm.nih.gov/pubmed/26006779)

Crohn’s disease is a chronic inflammatory disease of the intestine potentially affecting all parts of the intestine with predilection sites in the terminal ileum and proximal colon. Its prevalence in Western Europe is 20-40/100,000 with equal affection of both sexes and familiar accumulation. Histopathologically, it is characterized by a discontinuous, segmental manifestation and implication of all intestinal layers. Celiac disease, on the other hand, is defined by histologically proven villous atrophy associated with hyperplasia of crypts, lymphocytic infiltration and clinical improvement after a gluten-free diet.

We report the case of a 52-year-old man presenting with long-term diarrhea and loss of weight associated with Crohn’s disease. After interventional therapy for an unstable coronary artery syndrome and medical therapy for hyperthyroidism, the diarrhea stopped only after maintaining a gluten-free diet. A latent form of celiac disease (clinical symptoms, improvement after gluten-free diet, detection of anti-gliadin IgA antibodies, negative histology) was diagnosed.

To our knowledge, this is the first report on the association of Crohn’s disease and the latent form of celiac disease in the same patient. Whereas in most cases, Crohn’s disease develops secondary to a pre-existing celiac disease, in our patient, latent celiac disease was diagnosed years after the onset of and therapy for Crohn’s disease.

http://www.ncbi.nlm.nih.gov/pubmed/15578194

“Most importantly, gluten-fortified experimental diet induced chronic ileitis… Gluten was identified as antigen-independent dietary factor relevant for the induction of chronic inflammation in the small intestine…”

http://www.ncbi.nlm.nih.gov/pubmed/23567784

 

 

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